Clinical Chemistry
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Clinical Chemistry 22: 851-855, 1976;
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Clinical Chemistry, Vol 22, 851-855, Copyright © 1976 by American Association for Clinical Chemistry

Serum theophylline analysis by high-pressure liquid chromatography

MA Evenson and BL Warren

We have developed and evaluated a rapid, high-pressure liquid- chromatographic method for theophylline in serum. Only 0.2 ml of serum is required for each determination, and the sensitivity of this method is 0.5 mg/liter. This method, involving liquid extraction and silica adsorption chromatography, provides adequate selectivity, accuracy, and precision for routine or research applications. Little sample preparation is required before chromatography. We found no endogenous or exogenous interferences. Use of beta-hydroxypropyl theophylline as the internal standard provides reproducible results for this micro- scale method.


The following articles in journals at HighWire Press have cited this article:


Home page
 Arch Pediatr Adolesc MedHome page
F. E. R. Simons, F. R. Friesen, and K. J. Simons
Theophylline Toxicity in Term Infants
Arch Pediatr Adolesc Med, January 1, 1980; 134(1): 39 - 41.
[Abstract] [PDF]


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Copyright © 1976 by the American Association for Clinical Chemistry.