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Clinical Chemistry 22: 889-891, 1976;
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Clinical Chemistry, Vol 22, 889-891, Copyright © 1976 by American Association for Clinical Chemistry

Diazepam abuse: incidence, rapid screening, and confirming methods

TA Rejent and KC Wahl

We studied 2500 patients suspected to be drug-overdose victims. Blood samples were quantitatively screened for the most commonly abused drugs, including diazepam. Of these, 61% had positive findings, including diazepam in about one of every four. A new rapid, simple, and quantitative gas-chromatographic method for simultaneous analysis of diazepam and sedatives (in two instruments) is described. A single extraction at low pH is used, preserving the balance of the sample to be used for confirming methods via ultraviolet spectrophotometry and thin-layer chromatography. Prevalance of other positive findings is also listed, and findings for diazepam are categorized by age.




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Copyright © 1976 by the American Association for Clinical Chemistry.