Clinical Chemistry
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Clinical Chemistry 22: 1070-1072, 1976;
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Clinical Chemistry, Vol 22, 1070-1072, Copyright © 1976 by American Association for Clinical Chemistry

Determination of carbamazepine in blood or plasma by high-pressure liquid chromatography

PM Kabra and LJ Marton

We described a sensitive and precise high-pressure liquid- chromatographic method in which 5-(p-methylphenyl)-5-phenylhydantoin is used as the internal standard in determining carbamazepine in whole blood or plasma. Carbamazepine is well separated from normal blood constituents in less than 8 min, and other commonly used anticonvulsants do not interfere with the analysis. The sensitivity of this method is adequate to quantitate 0.25 mg of carbamazepine per liter in 2 ml of sample, and the lower limit of detection is 100 ng. Twenty specimens were analyzed by a gas-chromatographic method and by the present method; the resulting correlation coefficient was greater than .980.




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Copyright © 1976 by the American Association for Clinical Chemistry.