Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 22: 1319-1321, 1976;
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McBay, A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by McBay, A.

Clinical Chemistry, Vol 22, 1319-1321, Copyright © 1976 by American Association for Clinical Chemistry

Propoxyphene and norpropoxyphene concentrations in blood and tissues in cases of fatal overdose

AJ McBay

Propoxyphene and its major metabolite, norpropoxyphene, have been quantitated in tissue specimens obtained from autopsies of people suspected of dying from propoxyphene overdosage. Gas-chromatographic determination of both propoxyphene and norpropoxyphene is essential because the blood concentration of the parent drug should be about 1.0 mg/liter or greater to attribute a death to the drug. The metabolite concentration in blood may help to establish when the drug was ingested. Concentrations in the blood after high oral therapeutic doses are about 0.3 mg of propoxyphene per liter, and norpropoxyphene concentrations may be as high as 3 mg/liter. Methods of determining propoxyphene are discussed.


The following articles in journals at HighWire Press have cited this article:


Home page
 Hum Exp ToxicolHome page
A.T. Proudfoot
Clinical Features and Management of Distalgesic Overdose
Human and Experimental Toxicology, January 1, 1984; 3(1_suppl): 85s - 94S.
[Abstract] [PDF]

Home page
 Hum Exp ToxicolHome page
B.M. Buckley and J.A. Vale
Dextropropoxyphene Poisoning: Problems with Interpretation of Analytical Data
Human and Experimental Toxicology, January 1, 1984; 3(1_suppl): 95s - 101S.
[Abstract] [PDF]

Home page
 Hum Exp ToxicolHome page
J.A. Vale, B.M. Buckley, and T.J. Meredith
Deaths from Paracetamol and Dextropropoxyphene (Distalgesic) Poisoning in England and Wales in 1979
Human and Experimental Toxicology, January 1, 1984; 3(1_suppl): 135s - 143S.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1976 by the American Association for Clinical Chemistry.