Clinical Chemistry, Vol 22, 1366-1371, Copyright © 1976 by American Association for Clinical Chemistry

Correlation between estrogen receptor protein and carcinoembryonic antigen in normal and carcinomatous human breast tissue

CJ Menendez-Botet, JS Nisselbaum, M Fleisher, PP Rosen, A Fracchia, G Robbins, JA Urban and MK Schwartz

We determined estrogen receptor protein and carcinoembryonic antigen in cytosols prepared from 189 human breast carcinoma tissues, 85 benign or normal breast biopsies, and 101 tissue specimens metastatic from breast carcinoma. Carcinoembryonic antigen was observed in 70% of the primary carcinomatous tissues, 15% of the benign or normal specimens, and 51% of the metastases. Ninety-six of the 189 primary carcinomatous specimens with increased concentrations of carcinoembryonic antigen were also positive for estrogen receptor protein, whereas 67 of the 72 benign or normal biopsies with low concentrations of carcinoembryonic antigen were also negative for estrogen receptor protein. All five fenign specimens with positive estrogen receptor protein and normal carcinoembryonic antigen concentrations were from fibroadenomas. The concordance between estrogen receptor protein and carcinoembryonic antigen in the primary carcinomatous tissue was 66%, in metastatic carcinoma 51%, and in benign and normal tissue 85%.

The following articles in journals at HighWire Press have cited this article:

				D. W. Kinne, J. A. Butler, M. Kimmel, B. J. Flehinger, C. Menendez-Botet, and M. Schwartz Estrogen Receptor Protein of Breast Cancer in Patients With Positive Nodes: High Recurrence Rates in the Postmenopausal Estrogen Receptor--Negative Group Arch Surg, November 1, 1987; 122(11): 1303 - 1306. [Abstract] [PDF]

				J. E. McClendon, D. Appleby, D. B. Claudon, W. L. Donegan, and J. J. DeCosse Colonic Neoplasms: Tissue Estrogen Receptor and Carcinoembryonic Antigen Arch Surg, March 1, 1977; 112(3): 240 - 241. [Abstract] [PDF]