Clinical Chemistry
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Clinical Chemistry 22: 1392-1393, 1976;
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Clinical Chemistry, Vol 22, 1392-1393, Copyright © 1976 by American Association for Clinical Chemistry

Factors influencing results for thyroxine concentration in blood, as measured in paper filter spots in a screening program for neonatal hypothyroidism

JH Dussault, J Morissette, P Fiset, E Laberge and C Laberge

To reduce the number of false-positives in our screening program for neonatal hypothyroidism, we investigated the effect of age, body weight, and interval between sampling and analysis on results for filter paper spot thyroxine determination. The statistical analysis included an analysis of covariance. The age of the infant did not influence the results, the interval influenced them minimally, but weight did require a correction factor of about 0.16 ng/kg below the mean weight. This correction factor should reduce our false-positives from 0.75% to 0.60%. Furthermore, because all hypothyroid infants had results that fell more than 2.8 SD below the geometric mean, we intend to measure thyrotropin concentrations in the blood eluate of all the spots with a thyroxine concentration below that cut-off point.


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M. Kloosterboer, G. Hoffman, M. Rock, W. Gershan, A. Laxova, Z. Li, and P. M. Farrell
Clarification of Laboratory and Clinical Variables That Influence Cystic Fibrosis Newborn Screening With Initial Analysis of Immunoreactive Trypsinogen
Pediatrics, February 1, 2009; 123(2): e338 - e346.
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Copyright © 1976 by the American Association for Clinical Chemistry.