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Clinical Chemistry 23: 112-115, 1977;
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Clinical Chemistry, Vol 23, 112-115, Copyright © 1977 by American Association for Clinical Chemistry

Automated computer analysis for enzyme-multiplied immunological techniques

D Rodbard and SW McClean

The dose/response curve in enzyme-multiplied immunoassays (EMIT) and related techniques may be described by the same "four-parameter logistic function" as has proven useful in radioimmunoassays, immunoradiometric assays (IRMA), and two-site immunoradiometric ("sandwhich") assays. This function provides an empirical description of the dose/response curve by use of an objective least-squares regression analysis, with the advantages of computerization and automation. This facilitates further statistical analyses, quality control, estimation of precision for an unknown, and improved, objective estimation of the sensitivity or minimal detectable dose.




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Copyright © 1977 by the American Association for Clinical Chemistry.