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Clinical Chemistry 23: 64-68, 1977;
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Clinical Chemistry, Vol 23, 64-68, Copyright © 1977 by American Association for Clinical Chemistry

Gas-chromatographic/mass-spectrometric determination of theophylline in whole blood

M Sheehan, RH Hertel and CT Kelly

We describe a combined gas-chromatographic mass-spectrometric method for determination of theophylline in whole blood. With use of a probability-based matching approach, the extensive gas-chromatographic interference did not affect mass-spectrometric quantitation of theophylline. Concentrations expected and found were linearly related from 1 to 60 mg/liter; the run-to-run coefficient of variation was less than 8%, within-run less than 6%. Some other xan-thines and drugs frequently co-administered with theophylline did not affect results. Only 0.2 ml of blood is required, which makes the procedure useful for monitoring theophylline in newborns and pediatric populations.




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Copyright © 1977 by the American Association for Clinical Chemistry.