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Clinical Chemistry 23: 1989-1994, 1977;
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Clinical Chemistry, Vol 23, 1989-1994, Copyright © 1977 by American Association for Clinical Chemistry

Radioimmunoassay of parathyroid hormone (parathyrin) in monkey and man

GK Hargis, GA Williams, WA Reynolds, W Kawahara, B Jackson, EN Bowser and RM Pitkin

A radioimmunoassay for rhesus monkey and human immunoreactive parathyrin was developed in which a selected anti-bovine parathyrin antiserum, radioiodinated purified bovine parathyrin tracer, and human parathyroid tissue-culture media standards were used. The resulting data indicate that (a) the method is sensitive, specific, accurate and reproducible; (b) it is valid for both the rhesus monkey and the human; (c) the serum immunoreactive parathyrin concentration of the monkey is essentially the same as that in man; (d) monkey immunoreactive parathyrin responds to changes in serum calcium concentration similarly to that in man; and (e) the rhesus monkey is therefore a suitable species in which to study parathyroid physiology, from which conclusions can be applied to the human.


The following articles in journals at HighWire Press have cited this article:


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 Am. J. Physiol. Endocrinol. Metab.Home page
S. B. Arnaud, M. Navidi, L. Deftos, M. Thierry-Palmer, R. Dotsenko, A. Bigbee, and R. E. Grindeland
The calcium endocrine system of adolescent rhesus monkeys and controls before and after spaceflight
Am J Physiol Endocrinol Metab, March 1, 2002; 282(3): E514 - E521.
[Abstract] [Full Text] [PDF]


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Copyright © 1977 by the American Association for Clinical Chemistry.