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Clinical Chemistry 23: 2039-2042, 1977;
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Clinical Chemistry, Vol 23, 2039-2042, Copyright © 1977 by American Association for Clinical Chemistry

Removal of an endogenous antigen from an antibody to increase its effective affinity constant, as illustrated by triiodothyronine assay

LK Oliver and C Cano

Antisera to triiodothyronine were shown to contain large quantities of the hormone, well in excess of normal circulating concentrations. Extracting the triiodothyronine from the antiserum with alkaline ethanol yielded an antibody of increased affinity. Use of this antibody in a radioimmunoassay resulted in a fourfold increase in sensitivity as compared with the unextracted material.




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Copyright © 1977 by the American Association for Clinical Chemistry.