Clinical Chemistry
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Clinical Chemistry 23: 2085-2088, 1977;
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Clinical Chemistry, Vol 23, 2085-2088, Copyright © 1977 by American Association for Clinical Chemistry

Radioimmunoassay for flupenthixol in plasma

JD Robinson and D Risby

We describe a radioimmunoassay for the neuroleptic drug flupenthixol, suitable for routine monitoring of its concentration in blood. Antibodies for the assay were raised in a sheep against a 7- carboxyflupenthixol/ovalbumin conjugate. The resulting assay, with [3H] flupenthixol as the label, is capable of detecting 2.0 microgram of flupenthixol per liter, in a 100-microliter plasma sample. The antiserum shows no cross reactivity with tricyclic drugs and low interference from the major metabolites of flupenthixol. Concentrations in plasma after a single oral dose of flupenthixol have been followed in one volunteer. Peak values were reached after 3 h. Determinations of flupenthixol after fortnightly intramuscular depot injections of the sustained-release preparation, flupenthixol decanoate, showed the extent of fluctuations during this period.


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 Arch Gen PsychiatryHome page
R. T. Rubin, A. Forsman, J. Heykants, R. uhman, and M. Michiels
Serum Haloperidol Determinations in Psychiatric Patients: Comparison of Methods and Correlation With Serum Prolactin Level
Arch Gen Psychiatry, September 1, 1980; 37(9): 1069 - 1074.
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Copyright © 1977 by the American Association for Clinical Chemistry.