Clinical Chemistry
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Clinical Chemistry 23: 2207-2212, 1977;
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Clinical Chemistry, Vol 23, 2207-2212, Copyright © 1977 by American Association for Clinical Chemistry

High-performance liquid-chromatographic assay for nitrofurantoin in plasma and urine

MB Aufrere, B Hoener and ME Vore

The high-performance liquid-chromatographic method described here for the quantitative analysis for nitrofurantoin in urine and plasma involves direct analysis of urine samples and analysis of plasma samples after protein precipitation by methanol. The assay, which requires only 0.2 ml of biological fluid and shows a linear relationship in the range 0.02 to 200 mg/liter, can be performed in 9 min and is reproducible (CV less than 2%). Results for nitrofurantoin so obtained correlate well with those obtained by the Hyamine 10-X spectrophotometric method (CV = 2%), but the present method is more sensitive. With no modification, the present procedure can also be used for nitrofurazone. The sensitivity, accuracy, and convenience of the method make it suitable for clinical monitoring and pharmacokinetic/bioavailability studies with 5-nitrofuran derivatives.


The following articles in journals at HighWire Press have cited this article:


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 J. Pharmacol. Exp. Ther.Home page
F. W. Kari, R. Weaver, and M. C. Neville
Active Transport of Nitrofurantoin Across the Mammary Epithelium In Vivo
J. Pharmacol. Exp. Ther., February 1, 1997; 280(2): 664 - 668.
[Abstract] [Full Text]


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Copyright © 1977 by the American Association for Clinical Chemistry.