Clinical Chemistry
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Clinical Chemistry 23: 469-472, 1977;
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Clinical Chemistry, Vol 23, 469-472, Copyright © 1977 by American Association for Clinical Chemistry

Alkaline phosphatase activity in the plasma of children and adolescents

GA Fleisher, ES Eickelberg and LR Elveback

We determined plasma (serum alkaline phosphatase activity in 854 healthy students of the Rochester, Minnesota, public schools. Prepubertal girls had somewhat greater upper limits than did boys, and there was a low trend of increasing activity in both sexes. At the beginning of adolescence increasing activities were observed, which peaked at ages 11 to 12 years in girls and at ages 13 to 14 in boys. Adult values were not reached until six to eight years later. In 180 pairs of siblings, a significant intraclass correlation was noted. A possible role of alkaline phosphatase in the regulation of protein synthesis is suggested.


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P. G. Steinherz, L. J. Steinherz, J. S. Nisselbaum, and M. L. Murphy
Transient, Marked, Unexplained Elevation of Serum Alkaline Phosphatase
JAMA, December 21, 1984; 252(23): 3289 - 3292.
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Copyright © 1977 by the American Association for Clinical Chemistry.