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Clinical Chemistry 23: 1318-1320, 1977;
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Clinical Chemistry, Vol 23, 1318-1320, Copyright © 1977 by American Association for Clinical Chemistry

Determination of plasma procainamide and N-acetylprocainamide concentration by high-pressure liquid chromatography

JS Dutcher and JM Strong

We describe a routine method for determining concentrations of the antiarrhythmic drug procainamide and its active metabolite, N- acetylprocainamide, in plasma. A simple extraction of 1.0 ml of plasma is followed by separation and chromatographic analysis by use of a column containing microparticulate silica. p-nitro-N-(2- diethylaminoethyl)benzamide hydrochloride was synthesized and used as the internal standard. Total chromatographic time is only 7 min. The day-to-day CV during three months of daily use was less than 4% of the mean for each compound, and we saw no deterioration in column performance during this time. Phenobarbital, phenytoin, lidocaine, primidone, methsuximide, quinidine, and their metabolites do not interfere.




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Copyright © 1977 by the American Association for Clinical Chemistry.