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Clinical Chemistry, Vol 23, 1326-1328, Copyright © 1977 by American Association for Clinical Chemistry
F Dorrity Jr, M Linnoila and RL Habig
We describe a comprehensive gas chromatographic analysis for therapeutic concentrations of amitriptyline, nortriptyline, imipramine, desipramine, doxepin, and desmethyldoxepin in plasma, with use of a nitrogen detector. All these drugs are extracted and chromatographed under identical conditions. Each tertiary amine tricyclic is well resolved from its secondary amine metabolite on a mixed-phase column and the concentrations of both are determined simultaneously, without derivatization. The lower limit of sensitivity is 10 microgram/liter of plasma (2-ml sample). Analytical recoveries of the tertiary and secondary amines are 100 and 80%, respectively. Between-run CV's for all of the drugs ranged between 5 and 7%.
The following articles in journals at HighWire Press have cited this article:
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J. Davidson, M. McLeod, B. Law-Yone, and M. Linnoila A Comparison of Electroconvulsive Therapy and Combined Phenelzine-Amitriptyline in Refractory Depression Arch Gen Psychiatry, May 1, 1978; 35(5): 639 - 642. [Abstract] [PDF] |
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