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Clinical Chemistry 23: 1346-1347, 1977;
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Clinical Chemistry, Vol 23, 1346-1347, Copyright © 1977 by American Association for Clinical Chemistry

Heparin pretreatment suppresses norepinephrine concentrations in dogs in endotoxic shock

DF Devereux, CA Michas and S Rice

Mongrel dogs were treated intravenously with either 1000 units of beef- lung heparin per kilogram of body weight or with isotonic saline, before intravenous administration of E. coli endotoxin. We found significant differences in circulating norepinephrine concentrations between a heparin-pretreatment group (1.89 +/- 0.39 microgram/liter) and the control group (9.83 +/- 4.64 microgram/liter), but none with respect to epinephrine. Systolic blood pressures at 360 min were also significantly (P less than 0.05) different, 148 +/- 6 mmHg as compared with 118 +/- 13.4 mmHg. Evidently heparin pretreatment can decrease circulating norepinephrine concentrations in the endotoxic state and changes in circulating catecholamine concentrations can affect physiological variables.


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A. P. Kohm and V. M. Sanders
Norepinephrine and beta 2-Adrenergic Receptor Stimulation Regulate CD4+ T and B Lymphocyte Function in Vitro and in Vivo
Pharmacol. Rev., December 1, 2001; 53(4): 487 - 525.
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Copyright © 1977 by the American Association for Clinical Chemistry.