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Clinical Chemistry 23: 1666-1668, 1977;
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Clinical Chemistry, Vol 23, 1666-1668, Copyright © 1977 by American Association for Clinical Chemistry

Comparison of the Hoesch and the Watson-Schwartz tests for urinary porphobilinogen

CA Pierach, R Cardinal, I Bossenmaier and CJ Watson

A comparison of the Hoesch and the Watson-Schwartz tests shows that the latter, although slightly more complicated, generally yields more concise results and is superior in sensitivity and specificity for porphobilinogen. The recommendation of the Hoesch test for use as a "bedside screening" method seems unrealistic. Before the diagnosis of an "inducible" porphyria is made, a positive Hoesch test requires that indoles, indoleacetic acid, methyldopa, end-stage alcoholic malnutrition, and phenazopyridine HCl be excluded, to avoid misinterpretation.


The following articles in journals at HighWire Press have cited this article:


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 Clin. Chem.Home page
R. E. Ford, M. J. Magera, K. M. Kloke, P. A. Chezick, A. Fauq, and J. P. McConnell
Quantitative Measurement of Porphobilinogen in Urine by Stable-Isotope Dilution Liquid Chromatography-Tandem Mass Spectrometry
Clin. Chem., September 1, 2001; 47(9): 1627 - 1632.
[Abstract] [Full Text] [PDF]

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C. A. Pierach
Porphyria Conundrum
Clin. Chem., July 1, 1999; 45(7): 932 - 933.
[Full Text] [PDF]


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