Clinical Chemistry
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Clinical Chemistry 23: 1753-1756, 1977;
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Clinical Chemistry, Vol 23, 1753-1756, Copyright © 1977 by American Association for Clinical Chemistry

Comparison of enzyme immunoassay and gas chromatography for determination of carbamazepine and ethosuximide in human serum

L Sun and I Szafir

Patients' sera were analyzed for carbamazepine and ethosuximide by enzyme immunoassay (x) and gas chromatography (y), and the results were compared. The correlation coefficients were: for carbamazepine, x vs. y 0.94 (n = 93); for ethosuximide, x vs. y 0.99 (n = 30). These results suggest that the two methods could be used interchangeably. Ten serum samples supplemented with carbamazepine (2.5 to 12.5 mg/liter) and ethosuximide (20.0 to 130.0 mg/liter) were analyzed by both methods. The correlation coefficients were: x vs. y 0.99 (n = 10) for carbamazepine and x vs. y 0.99 (n =10) for ethosuximide.




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Copyright © 1977 by the American Association for Clinical Chemistry.