Clinical Chemistry
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Clinical Chemistry 24: 122-127, 1978;
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Clinical Chemistry, Vol 24, 122-127, Copyright © 1978 by American Association for Clinical Chemistry

Determination of some L-3,4-dihydroxyphenylalanine and dopamine metabolites in urine by means of mass fragmentography

FA Muskiet, DC Fremouw-Ottevangers, J van der Meulen, BG Wolthers and JA de Vries

We describe a mass-fragmentographic method for determination in urine of the following metabolites of L-3,4-dihydroxyphenylalanine and dopamine: vanillactic acid, 3,4-dihydroxyphenylacetic acid, 3-methoxy-4- hydroxyphenylethanol, and 3,4-dihydroxyphenylethanol. Deuterated analogs were used as internal standards. The method is fast, reproducible, sensitive, and selective, and does not require the use of time-consuming clean-up procedures. Normal excretion values in terms of creatinine, expressed as a function of age, as well as values obtained for patients with neurogenic tumors, a patient during therapy with L- 3,4-dihydroxyphenylalanine, and a patient receiving dopamine are presented and discussed.




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Copyright © 1978 by the American Association for Clinical Chemistry.