Clinical Chemistry AACC Online Job Center
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 24: 1734-1737, 1978;
This Article
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ashby, C. D.
Right arrow Articles by Nelson, J. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ashby, C. D.
Right arrow Articles by Nelson, J. C.

Clinical Chemistry, Vol 24, 1734-1737, Copyright © 1978 by American Association for Clinical Chemistry

Measurement of three aminoglycosiee antibiotics with a single radioimmunoassay system

CD Ashby, JE Lewis and JC Nelson

A versatile radioimmunoassay procedure has been developed to specifically assay gentamicin, tobramycin, or amikacin. Iodinated derivatives of these three antibiotics were prepared by a modified Bolton and Hunter procedure. A single reagent system composed of a pool of three very specific antisera was used in the procedure. The antisera combination did not alter the specificity of the procedure. Validation of the assay of the three antibiotics included studies of parallelism, accuracy, precision, reproducibility, and method comparison with other radioimmunoassay procedures involving single antiserum systems. We discuss the application of this multiple assay capability to other procedures involving use of immunochemicals.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1978 by the American Association for Clinical Chemistry.