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Clinical Chemistry 24: 1744-1750, 1978;
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Clinical Chemistry, Vol 24, 1744-1750, Copyright © 1978 by American Association for Clinical Chemistry

Determination of a trivariate reference region for free thyroxine index, free triiodothyronine index, and thyrotropin from results obtained in a health survey of middle-aged women

B Kagedal, A Sandstrom and G Tibbling

We measured free thyroxine index, free triiodothyronine index, and thyrotropin in serum in a community survey of the female population 39-- 60 years old. A statistical method using Mahalanobis' distance was applied to the data, to identify and eliminate highly abnormal values, "outliers." There was a small but statistically significant increase in each of the three hormones with age. After correction for age dependency, significant but rather small correlations were found between the hormones. The material was used to calculate univariate reference intervals and a trivariate 0.95-tolerance region.


The following articles in journals at HighWire Press have cited this article:


Home page
 J. Clin. Endocrinol. Metab.Home page
S. Andersen, K. M. Pedersen, N. H. Bruun, and P. Laurberg
Narrow Individual Variations in Serum T4 and T3 in Normal Subjects: A Clue to the Understanding of Subclinical Thyroid Disease
J. Clin. Endocrinol. Metab., March 1, 2002; 87(3): 1068 - 1072.
[Abstract] [Full Text] [PDF]


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Copyright © 1978 by the American Association for Clinical Chemistry.