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Clinical Chemistry 24: 2001-2008, 1978;
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Clinical Chemistry, Vol 24, 2001-2008, Copyright © 1978 by American Association for Clinical Chemistry

Determination of 3-methoxy-4-hydroxyphenylpyruvic acid, 3,4- dihydroxyphenylethylene glycol, and 3,4-dihydroxyphenylmandelic acid in urine by mass fragmentography, with use of deuterium-labeled internal standards

FA Muskiet, DC Fremouw-Ottevangers, GT Nagel, BG Wolthers and JA de Vries

We report the determination of 3-methoxy-4-hydroxyphenylpyruvic acid, 3,4-dihydroxyphenylmandelic acid, and 3,4-dihydroxyphenylethylene glycol in urine, by use of gas chromatography/mass spectrometry in combination with a simple purification method and deuterium-labeled internal standards. Normal excretion values in terms of creatinine, expressed as a function of age, are given, together with results obtained for patients with neuroblastoma, pheochromocytoma, or parkinsonism treated with L-DOPA + peripheral decarboxylase inhibitor, and for a patient receiving dopamine. We were unable to identify 3, 4- dihydroxyphenyllactic acid in urine. The results obtained and their relation to other catecholamine metabolites and catecholamine-precursor metabolites in urine are discussed.




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Copyright © 1978 by the American Association for Clinical Chemistry.