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Clinical Chemistry 24: 2158-2160, 1978;
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Clinical Chemistry, Vol 24, 2158-2160, Copyright © 1978 by American Association for Clinical Chemistry

Polystyrene tube immunoradiometric assay for human alpha1-fetoprotein, and its use for mass screening

A Grenier, J Morissette, JP Valet and L Belanger

We describe a two-site immunoradiometric assay for human alpha1- fetoprotein, with use of antibody-coated polystyrene tubes as solid phase. The sensitivity, precision, and simplicity of this system make it eminently suitable for mass-screening purposes. We currently use it for neonatal detection of hereditary tyrosinemia in the Province of Quebec; measurements are made on blood spotted and dried on paper. This system could be well suited for other mass surveys, such as prenatal screenings for fetal abnormalities.




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Copyright © 1978 by the American Association for Clinical Chemistry.