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Clinical Chemistry 24: 2186-2191, 1978;
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Clinical Chemistry, Vol 24, 2186-2191, Copyright © 1978 by American Association for Clinical Chemistry

Results with commercial radioassay kits compared with microbiological assay of folate in serum and whole-blood

EL McGown, CM Lewis, MH Dong and HE Sauberlich

We compared results with three commercial folate radioassay kits [Bio- Rad, New England Nuclear (NEN), and RIA Products] with those by microbiological assay for more than 200 samples of human serum and whole blood. All but one kit (NEN) compared favorably with the microbiological assay for serum samples, although there were notable diagnostic discrepancies. Two kits (NEN and Bio-Rad) were tested on whole-blood samples; both yielded values significantly higher than those by microbiological assay. The frequency distributions of erythrocyte folate data differed strikingly between the two kits; the NEN method yielded a much narrower range of normal values than did either the Bio-Rad or the microbiological assay. Radioassay kits appear to be suitable diagnostic agents for serum folate, if the behavior of a particular kit is investigated thoroughly before its routine use. However, the diagnostic value of radioassays of erythrocyte folate needs to be validated.


The following articles in journals at HighWire Press have cited this article:


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A. J. A. Wright, P. M. Finglas, and S. Southon
Erythrocyte Folate Analysis: Saponin Added During Lysis of Whole Blood Can Increase Apparent Folate Concentrations, Depending on Hemolysate pH
Clin. Chem., December 1, 2000; 46(12): 1978 - 1986.
[Abstract] [Full Text] [PDF]

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A. J. A. Wright, P. M. Finglas, and S. Southon
Erythrocyte folate analysis: a cause for concern?
Clin. Chem., September 1, 1998; 44(9): 1886 - 1891.
[Abstract] [Full Text] [PDF]

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A. M. Molloy, J. L. Mills, P. N. Kirke, A. S. Whitehead, D. G. Weir, and J. M. Scott
Whole-Blood Folate Values in Subjects with Different Methylenetetrahydrofolate Reductase Genotypes: Differences Between the Radioassay and Microbiological Assays
Clin. Chem., January 1, 1998; 44(1): 186 - 188.
[Full Text]


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