Clinical Chemistry
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Clinical Chemistry 24: 256-260, 1978;
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Clinical Chemistry, Vol 24, 256-260, Copyright © 1978 by American Association for Clinical Chemistry

Automated assay of gamma-aminobutyric acid in human cerebrospinal fluid

P Bohlen, PJ Schechter, W van Damme, G Coquillat, JC Dosch and J Koch-Weser

We describe an automated amino acid analyzer with fluorescence detection (o-phthalaldehyde) which permits sensitive and rapid determinations of gamma aminobutyric acid in human cerebrospinal fluid. Concentrations as low as 50 nmol/liter can be accurately determined in 100 mul samples at the rate of one sample per hour. Concentrations in untreated cerebrospinal fluid increase rapidly after sampling by lumbar puncture. The concentration in immediately deproteinized samples from 38 patients with intervertebral disc disorders was 220 +/- 81 nmol/liter (mean +/- SD).


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R. Zimmer, A. W. Teelken, W. B. Trieling, W. Weber, T. Weihmayr, and H. Lauter
{gamma}-Aminobutyric Acid and Homovanillic Acid Concentration in the CSF of Patients With Senile Dementia of Alzheimer's Type
Arch Neurol, June 1, 1984; 41(6): 602 - 604.
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S. R. Bareggi, M. Franceschi, L. Bonini, L. Zecca, and S. Smirne
Decreased CSF Concentrations of Homovanillic Acid and {gamma}-Aminobutyric Acid in Alzheimer's Disease: Age- or Disease-Related Modifications?
Arch Neurol, November 1, 1982; 39(11): 709 - 712.
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T. A. Hare, J. H. Wood, and B. V. Manyam
Clinical Implications of Enzyme-Mediated Alterations of {gamma}-Aminobutyric Acid Content in Human CSF
Arch Neurol, August 1, 1981; 38(8): 491 - 494.
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N. V. B. Manyam, L. Katz, T. A. Hare, J. C. Gerber III, and M. H. Grossman
Levels of {gamma}-Aminobutyric Acid in Cerebrospinal Fluid in Various Neurologic Disorders
Arch Neurol, June 1, 1980; 37(6): 352 - 355.
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Copyright © 1978 by the American Association for Clinical Chemistry.