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Clinical Chemistry 24: 357-360, 1978;
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Clinical Chemistry, Vol 24, 357-360, Copyright © 1978 by American Association for Clinical Chemistry

High-performance liquid-chromatographic determination theophylline in plasma

GW Peng, MA Gadalla and WL Chiou

A high-performance liquid-chromatographic method is reported for monitoring theophylline in plasma. Samples are deproteinized with 2.5 volumes of acetonitrile and the supernates chromatographed on a reversed-phase column. Absorption at 275 nm is monitored. One can accurately measure 1.5 mg of theophylline per liter, in as little as 10 microliter of plasma, and only about 7 min is required per sample. No interference was found in plasma samples from asthmatic patients. This method is particularly useful for routine therapeutic monitoring of both pediatric and adult patients.




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