Clinical Chemistry
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Clinical Chemistry 24: 403-413, 1978;
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Clinical Chemistry, Vol 24, 403-413, Copyright © 1978 by American Association for Clinical Chemistry

Performance evaluation of multi-channel analyzers by use of linearly- related survey specimens

TE Caragher and GF Grannis

Sets of specimens having quantitative linear inter-relationships for 25 analytes were prepared and used in a small survey of results with multi- channel analyzers. Instrument calibration was evaluated by linear regression analysis of the analytical results, with calculation of the x- and y-intercepts and slopes. The average intercepts and slopes agreed quite well with those expected on the basis of specimen preparation, but the results from individual laboratories and from particular kinds of instruments demonstrated a variety of analytical biases. We conclude that performance of multi-channel analyzers can be evaluated effectively by such use of linearly related specimens in an inter-laboratory survey.




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Copyright © 1978 by the American Association for Clinical Chemistry.