Clinical Chemistry
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Clinical Chemistry 24: 429-432, 1978;
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Clinical Chemistry, Vol 24, 429-432, Copyright © 1978 by American Association for Clinical Chemistry

Radioimmunoassay for mono-(2-ethylhexyl) phthalate in unextracted plasma

MI Luster, PW Albro, K Chae, G Clark and JD McKinney

We report a radioimmunoassay for mono-(2-ethylhexyl) phthalate that has been coupled to a protein carrier as a radioligand. Competitive interference tests with a variety of related compounds indicated the assay to be highly specific. Quantitative comparison of mono-(2- ethylhexyl) phthalate values in plasma and serum samples between the radioimmunoassay and gas chromatographic procedures indicated a high reliability. Because this potentially toxic compound can leach into plasma from polyvinyl plastics, this assay should be particularly useful for those involved in the manufacture or use of medical devices made of them.




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Copyright © 1978 by the American Association for Clinical Chemistry.