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Clinical Chemistry 24: 706-709, 1978;
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Clinical Chemistry, Vol 24, 706-709, Copyright © 1978 by American Association for Clinical Chemistry

Cross reactivity of digitoxin and spironolactone in two radioimmunoassays for serum digoxin

H Muller, H Brauer and B Resch

We measured the cross reactivity of two medications--digitoxin and spironolactone--in two digoxin radioimmunoassay (liquid and solid- phase) kit procedures. Both tests showed similar average percentages of cross reactivity with digitoxin (7.2 and 8.9% for intravenous, and 11.9 and 10.9% for oral administration), but no cross reactivity with spironolactone or its metabolites after equal intravenous or oral doses.




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Copyright © 1978 by the American Association for Clinical Chemistry.