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Clinical Chemistry 24: 895-899, 1978;
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Clinical Chemistry, Vol 24, 895-899, Copyright © 1978 by American Association for Clinical Chemistry

Analysis for carbamazepine in serum by electron-capture gas chromatography

HA Schwertner, HE Hamilton and JE Wallace

We describe an analytical method for determining carbamazepine in serum by electron-capture gas chromatography. A single-step extraction is followed by formation of the N-pentafluorobenzamide derivative with pentafluorobenzoyl chloride. For quantitation either of two internal standards may be used: 10-methoxy carbamazepine or 7-chloro-5,11- dihydrodibenz[b,e] [1,4]-oxazepine-5-carboxamide (Squibb Compound No. 10996). The procedure requires 0.5 ml of serum. Analytical recoveries are 96%. Coefficients of variation routinely are less than 2% for concentrations of carbamazepine that are within the therapeutic range.




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Copyright © 1978 by the American Association for Clinical Chemistry.