Clinical Chemistry
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Clinical Chemistry 24: 1573-1575, 1978;
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Clinical Chemistry, Vol 24, 1573-1575, Copyright © 1978 by American Association for Clinical Chemistry

Gas-liquid chromatographic determination of bupivacaine and lidocaine in plasma

E Zylber-Katz, L Granit and M Levy

A modified gas-liquid chromatographic method for determining plasma concentrations of bupivacaine and lidocaine is described, with cyclizine as an internal standard. The extraction procedure requires no solvent evaporation, thus overcoming the problem of drug volatility. Concentrations as low as 0.1 mg/liter can be determined. The plasma sample is made alkaline and extracted into n-hexane, re-extracted into a small volume of an aqueous acid phase, and finally extracted into 50 microliter of methylene chloride after alkalinization. The final extract is assayed by gas chromatography on a 5% OV-17 column. The extraction scheme of the present method eliminates interferences by endogenous plasma constituents.




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Copyright © 1978 by the American Association for Clinical Chemistry.