Clinical Chemistry
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Clinical Chemistry 24: 1599-1602, 1978;
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Clinical Chemistry, Vol 24, 1599-1602, Copyright © 1978 by American Association for Clinical Chemistry

Measurement of chloroprocaine and procaine in plasma by flame ionization gas-liquid chromatography

RH Smith, MA Brewster, JA MacDonald and DS Thompson

We describe an isothermal gas-liquid chromatographic procedure developed for measuring procaine and chloroprocaine in plasma. The unchanged drug is extracted into toluene from alkalinized plasma, together with an internal standard. The solvent is removed, the residue redissolved in methanol, and aliquots are injected into a 91.5-cm gas- liquid chromatographic column containing 3% OV-210. Sensitivity of detection is in the nanogram range.





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Copyright © 1978 by the American Association for Clinical Chemistry.