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Clinical Chemistry 24: 1628-1630, 1978;
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Clinical Chemistry, Vol 24, 1628-1630, Copyright © 1978 by American Association for Clinical Chemistry

Detection of hemophilia A carriers by use of frozen plasma samples

HC Yang, J Hardin and C Vaudreuil

The efficacy of using promptly frozen plasma samples in the diagnosis of the carrier state for hemophilia A was evaluated by simultaneous measurement of factor VIII acitivity and antigen in 20 normal women and 20 obligate carriers. Factor VIII antigen was measured by two methods, electroimmunoassay and immunoradiometric assay. When the factor VIII activity and antigen data were evaluated by regression analysis, 94% of the carriers were correctly identified at the 95% confidence level.




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Copyright © 1978 by the American Association for Clinical Chemistry.