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Clinical Chemistry 25: 44-47, 1979;
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Clinical Chemistry, Vol 25, 44-47, Copyright © 1979 by American Association for Clinical Chemistry

Iodinated digoxin derivatives with improved reactivity and stability, for use in radioimmunoassay

EW Weiler and MH Zenk

We report the synthesis and properties of a new digoxin derivative, prepared by reacting cyanogen bromide-activated digoxin with tyramine. The derivative is extremely stable, and its monoiodinated form can be isolated in 85--90% purity by a single thin-layer chromatographic step. [125I]Tyramine-digoxin is immunologically stable for at least four months (immunoreactivities, 90% or greater throughout), with a shelf life of about six months. Nonspecific binding of less than 10% was observed for several batches during this time.




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Copyright © 1979 by the American Association for Clinical Chemistry.