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Clinical Chemistry 25: 1739-1743, 1979;
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Clinical Chemistry, Vol 25, 1739-1743, Copyright © 1979 by American Association for Clinical Chemistry

Metabolic balance of aluminum studied in six men

JE Gorsky, AA Dietz, H Spencer and D Osis

The metabolism of aluminum was followed in patients who were receiving strictly controlled diets, either unaltered or supplemented with aluminum-containing antacids. Aluminum was determined by atomic absorption spectrophotometry with a graphite furnace. All food, water, and medications were analyzed, as were aliquots of urine and stool collected throughout six-day periods. Patients were usually studied for five consecutive six-day periods on the same diet and aluminum intake. This study included six patients who were studied for seven to 21 such six-day periods. During control periods, when the patients were receiving less than 5 mg of aluminum per day, the balance was usually slightly negative, but when the diet was supplemented with antacids to contain 1--3 g of aluminum per day, an average positive balance of 23 to 313 mg of aluminum per day was observed for the total time on the same intake. Consecutive six-day periods while a subject was receiving antacids might show either positive or negative balances, but the average retention for 18--84 days on antacids was always positive. Thus the potential effects of the storage of aluminum in the tissues must be considered in the chronic administration of antacids.


The following articles in journals at HighWire Press have cited this article:


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 The Journal of the Royal Society for the Promotion of HealthHome page
A. Rowland, R. Grainger, R. S. Smith, N. Hicks, and A. Hughes
Water Contamination in North Cornwall: A Retrospective Cohort Study into the Acute and Short- Term Effects of the Aluminium Sulphate Incident in July 1988
The Journal of the Royal Society for the Promotion of Health, October 1, 1990; 110(5): 166 - 172.
[Abstract]


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Copyright © 1979 by the American Association for Clinical Chemistry.