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Clinical Chemistry 25: 1806-1809, 1979;
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Clinical Chemistry, Vol 25, 1806-1809, Copyright © 1979 by American Association for Clinical Chemistry

Increase in dialyzable calcium associated with therapy with lithium

J Toffaletti, RB McComb and GN Bowers Jr

We measured total and dialyzable calcium concentrations in consecutive sera submitted for routine lithium analysis. Of 98 samples from 61 different individuals, six (6.1%) total calcium results and 32 (33%) dialyzable calcium results were above the respective reference intervals. By comparison, when both total and dialyzable calcium were measured on 50 different apparently healthy volunteers, no results were outside either reference interval (2.20--2.58 mmol/L for total and 1.30- -1.47 mmol/L for dialyzable calcium). These increases were not due to age or sex differences between the patients and controls. From the dialyzable calcium data, there appears to be an even higher incidence of mild hypercalcemia in patients receiving oral lithium salts than is indicated by the total calcium concentration alone.




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Copyright © 1979 by the American Association for Clinical Chemistry.