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Clinical Chemistry 25: 1835-1837, 1979;
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Clinical Chemistry, Vol 25, 1835-1837, Copyright © 1979 by American Association for Clinical Chemistry

Fluorometric measurement of theophylline

JM Meola, HH Brown and T Swift

We have developed a simple, sensitive procedure in which theophylline in a solution of cerium(IV) acts as an oxidizable compound to produce fluorescent cerium(III) when combined with a microsolvent for extraction at pH 7.9. This method provides excellent sensitivity and specificity because other xanthines and phenobarbital, secobarbital, amobarbital, and phenytoin do not interfere. Day-to-day reproducibility (coefficient of variation, 6%) is attained for theophylline concentrations of 10 and 20 mg/L. Results correlate well with liquid chromatography and enzyme immunoassay procedures. Total analysis time for a single sample is 10 min.




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Copyright © 1979 by the American Association for Clinical Chemistry.