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Clinical Chemistry 25: 1909-1914, 1979;
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Clinical Chemistry, Vol 25, 1909-1914, Copyright © 1979 by American Association for Clinical Chemistry

Rate nephelometric measurement of rheumatoid factor in serum

PR Finley, MJ Hicks, RJ Williams, J Hinlicky and DA Lichti

We describe the measurement of rheumatoid factor in human sera with a rate nephelometer. The National Reference Preparation for Rheumatoid Factors is used to calibrate the assay in International Units. We used Hyland Positive Control, Level I, as a secondary standard. The standard curve is exponential, but is linear when plotted on log-log graph paper. Aggregated immune globulin (IgG) is the antigen used to detect rheumatoid factor (IgM-class antibody to IgG). The rate reaction measures the rate of increase in light-scatter by the antigen-antibody complexes; the reaction takes place in 17 to 20 s. Precision, linearity, and accuracy are excellent. Results agree well with those for a commonly used latex precipitation test. The advantages of speed, quantification in International Units, and superior discrimination of concentration as compared to serological titration provide a more reliable test for use in the diagnosis and treatment of rheumatoid arthritis.


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A. Al-Mekaimi, A. Malaviya, F. Serebour, I. Umamaheswaran, R. Kumar, K. Al-Saeid, and P. Sharma
Serological characteristics of systemic lupus erythematosus from a hospital-based rheumatology clinic in Kuwait
Lupus, January 1, 1997; 6(8): 668 - 674.
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