Clinical Chemistry
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Clinical Chemistry 25: 2045-2047, 1979;
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Clinical Chemistry, Vol 25, 2045-2047, Copyright © 1979 by American Association for Clinical Chemistry

Assay of 4-hydroxy-3-methoxyphenylacetic (homovanillic) acid by liquid chromatography with electrochemical detection

JL Morrisey and ZK Shihabi

We describe a method for the assay of urinary 4-hydroxy-3- methoxyphenylacetic acid (homovanillic acid), based on its separation on a microparticulate reversed-phase column and direct electrochemical detection. Patients with neuroblastoma, pheochromocytoma, and Parkinson's disease have increased amounts of this compound in their urine.




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Copyright © 1979 by the American Association for Clinical Chemistry.