Clinical Chemistry
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Clinical Chemistry 25: 2047-2049, 1979;
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Clinical Chemistry, Vol 25, 2047-2049, Copyright © 1979 by American Association for Clinical Chemistry

Blood thyroxine concentration is lower in low-birth-weight infants

JH Dussault, J Morissette and C Laberge

From out data bank, we analyzed results for thyroxine concentration in blood samples spotted on filter paper from different age groups (one to nine days postpartum) of our low-birth-weight and normal population. It was significantly lower in the low-birth-weight infants in almost all the age groups, and in both groups it significantly declined after postnatal day 5. The influence of weight is more important in the low- birth-weight population, but does not completely explain the smaller values. The results indicate that blood samples used in screening for congenital hypothyroidism in the neonate should be taken on postnatal days 3 to 5, and if a recall specimen is collected on days 5 to 9, one should expect the thyroxine concentration in the second specimen to be lower than in the first.




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Copyright © 1979 by the American Association for Clinical Chemistry.