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Clinical Chemistry 25: 218-220, 1979;
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Clinical Chemistry, Vol 25, 218-220, Copyright © 1979 by American Association for Clinical Chemistry

Gas-liquid chromatographic determination of mono- and diiodotyrosines in serum

LG Davis, NL Sass, B Manna and ML Nusynowitz

A sensitivie, reliable gas-chromatographic assay for monoiodotyrosine and diiodotyrosine in human serum is reported. The oxazolidinone- heptafluorobutyric anhydride derivatives allow the quantitation of both compounds in the linear range of 0.2 to 7.6 mg/L of serum. Analytical recovery averaged 88%, and mean accuracy and within-run precision were 98 and 2%, respectively. Concentrations of monoiodotyrosine in serum as low as 20 microgram/L and of diiodotyrosine as low as 100 microgram/L can be detected. Normal serum contains no detectable concentration of either compound, but the method is applicable as a diagnostic tool in the early prediction of thyroid disease. Both compounds were detected in the serum of a hypothyroid subject whose normal thyroid hormone concentrations were being maintained by therapy with desiccated thyroid extract.




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Copyright © 1979 by the American Association for Clinical Chemistry.