Clinical Chemistry
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Clinical Chemistry 25: 453-460, 1979;
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Clinical Chemistry, Vol 25, 453-460, Copyright © 1979 by American Association for Clinical Chemistry

Determination of catecholamines and their 3-O-methylated metabolites in urine by mass fragmentography with use of deuterated internal standards

FA Muskiet, CG Thomasson, AM Gerding, DC Fremouw-Ottevangers, GT Nagel and BG Wolthers

We report the determination of catecholamines (dopamine, norepinephrine, and epinephrine) and their 3-O-methylated metabolites (3-methoxytyramine, normetanephrine, and metanephrine) in urine by gas chromatography/mass spectrometry, with use of stable isotopically labeled internal standards. Normal excretion values in terms of creatinine, expressed as a function of age, are given, together with results obtained for patients with neuroblastoma, ganglioneuroblastoma, pheochromocytoma, parkinsonism treated with L-DOPA plus peripheral decarboxylase inhibitor, and a patient with cardiogenic shock treated with dopamine. The results obtained for normal adults are discussed in relation to other catecholamine metabolites and mean overall catecholamine turnover.




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Copyright © 1979 by the American Association for Clinical Chemistry.