Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 25: 943-947, 1979;
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by James, G. P.
Right arrow Articles by Harrison, R. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by James, G. P.
Right arrow Articles by Harrison, R. L.

Clinical Chemistry, Vol 25, 943-947, Copyright © 1979 by American Association for Clinical Chemistry

Creatine kinase isoenzymes of mitochondrial origin in human serum

GP James and RL Harrison

We measured creatine kinase (EC 2.7.3.2) activity in 1009 serum samples from 538 patients in the intensive-care units of the University of Texas Medical Branch hospitals. Creatine kinase isoenzymes migrating cathodal to skeletal muscle creatine kinase (CK-MM) on cellulose acetate electrophoresis were found in sera from 14 of the 538 patients. Creatine kinase, lactate dehydrogenase (EC 1.1.1.27), aspartate aminotransferase (EC 2.6.1.1), and alanine aminotransferase (EC 2.6.1.2) activities were abnormally increased in these 14 patients. Liver lactate dehydrogenase isoenzyme (LDH5) and cardiac creatine kinase isoenzyme (CK-MB) were abnormally increased in 12 and eight of these patients, respectively. Ten of the 14 patients died during their hospital admission. We believe the creatine kinase isoenzymes that migrated cathodal to skeletal muscle creatine kinase (CK-MM) were of mitochondrial origin.


The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
H. Yamamichi, S. Kasakura, S. Yamamori, R. Iwasaki, T. Jikimoto, S. Kanagawa, J. Ohkawa, S. Kumagai, and M. Koshiba
Creatine Kinase Gene Mutation in a Patient with Muscle Creatine Kinase Deficiency
Clin. Chem., November 1, 2001; 47(11): 1967 - 1973.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
C. J. Bark
Mitochondrial Creatine Kinase: A Poor Prognostic Sign
JAMA, May 23, 1980; 243(20): 2058 - 2060.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1979 by the American Association for Clinical Chemistry.