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Clinical Chemistry 25: 969-972, 1979;
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Clinical Chemistry, Vol 25, 969-972, Copyright © 1979 by American Association for Clinical Chemistry

Automated measurement of the elastase-inhibitory capacity of plasma with a centrifugal analyzer

T Klumpp and JG Bieth

We describe an automated method for measuring the elastase-inhibitory capacity of plasma. We use a GEMSAEC centrifugal analyzer and succinyltrialanine-p-nitroanilide as an elastase substrate. The method is fast (80--100 samples/h) and accurate (CV = 3.6%). The detection limits are from 20 to 300% of the normal value. The elastase-inhibitory capacity is well correlated with the trypsin-inhibitory capacity and with the immunochemically determined concentration of alpha 1- proteinase inhibitor (alpha 1-antitrypsin). Because elastase is not inhibited by other plasma inhibitors, this method can be used as an enzymatic technique for measuring the concentration of plasma alpha 1- proteinase inhibitor. In an apparently normal population, this concentration was 40 +/- 11 mumol/L.


The following articles in journals at HighWire Press have cited this article:


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 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. Borzone, L. Liberona, P. Olmos, C. Saez, M. Meneses, T. Reyes, R. Moreno, and C. Lisboa
Rat and hamster species differences in susceptibility to elastase-induced pulmonary emphysema relate to differences in elastase inhibitory capacity
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1342 - R1349.
[Abstract] [Full Text] [PDF]


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Copyright © 1979 by the American Association for Clinical Chemistry.