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Clinical Chemistry 25: 985-988, 1979;
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Clinical Chemistry, Vol 25, 985-988, Copyright © 1979 by American Association for Clinical Chemistry

Application of Bayes's theorem to results of quantitative clinical chemical determinations

HJ van der Helm and EA Hische

The diagnostic implication of a certain test result with regard to a certain condition can be expressed as a single number, L, the likelihood ratio of this result. This ratio allows Bayes's theorem to be written in a convenient form. We show that the practice of calculating predictive values for the results of quantitative tests by use of discrimination limits leads to incorrect predictive values. Including L values in laboratory reports seems a more logical approach to optimum interpretation of laboratory results than the use of discrimination values.


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