Clinical Chemistry
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Clinical Chemistry 25: 1368-1369, 1979;
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Clinical Chemistry, Vol 25, 1368-1369, Copyright © 1979 by American Association for Clinical Chemistry

Liquid-chromatographic measurement of taurine in cerebrospinal fluid of normal individuals and patients with meningitis

ZK Shihabi and JP White

Taurine was measured in cerebrospinal fluid by reacting it with fluorescamine to form a fluorescent derivative, followed by separation on a reversed-phase column and fluorometric detection and evaluation. The assay is rapid (17 min) and sensitive to as little as 1 mumol/L. The mean value for 27 cerebrospinal fluid samples collected from patients free from meningitis and aneurysm was 5.7 +/- 1.8 mumol/L. Twenty-two patients with bacterial meningitis showed a 0- to 20-fold increase in cerebrospinal fluid taurine, with a return to normal values after antibiotic treatment.




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Copyright © 1979 by the American Association for Clinical Chemistry.