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Clinical Chemistry 25: 1564-1571, 1979;
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Clinical Chemistry, Vol 25, 1564-1571, Copyright © 1979 by American Association for Clinical Chemistry

Plasma polyamines determined by negative-ion chemical ionization/mass spectrometry

JR Shipe Jr, DF Hunt and J Savory

We have developed an accurate and highly sensitive gas- chromatographic/mass-spectrometric procedure for determining di- and polyamines (putrescine, spermidine, and spermine) in plasma and erythrocytes. Deuterium-labeled analogs of putrescine, spermidine, and spermine were synthesized for use as internal standards. Trifluoroacetyl derivatives of the polyamines were formed during the procedure and then detected with negative-ion chemical ionization/mass spectrometry in combination with multiple ion monitoring. Limits of sensitivity ranged from 0.25 to 1.0 pmol of analyte injected into the instrument.




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