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Clinical Chemistry 26: 1897-1899, 1980;
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Clinical Chemistry, Vol 26, 1897-1899, Copyright © 1980 by American Association for Clinical Chemistry

Multivariate analysis of an enzymic profile for the differential diagnosis of viral hepatitis

G Plomteux

Differential diagnosis of acute viral hepatitis, persistent chronic hepatitis, aggressive chronic hepatitis, and post-necrotic cirrhosis can reasonably be achieved on the basis of three well-known liver- function tests: aspartate aminotransferase, alanine aminotransferase, and glutamate dehydrogenase. With use of principal-component analysis, these four liver diseases can be characterized by two criteria: a "cytolytic" criterion, correlated particularly with a membrane- permeability test--namely, alanine aminotransferase activity--and a "mitochondrial damage" criterion, which is associated with above-normal ornithine carbamyltransferase and glutamate dehydrogenase activities.




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Copyright © 1980 by the American Association for Clinical Chemistry.