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Clinical Chemistry 26: 1899-1902, 1980;
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Clinical Chemistry, Vol 26, 1899-1902, Copyright © 1980 by American Association for Clinical Chemistry

Interlaboratory evaluation of four RIA kits for determination of plasma cortisol, with special reference to accuracy: influence of matrix in calibration standards

O Lantto, I Bjorkhem, R Blomstrand and A Kallner

We used four RIA kits for determination of plasma cortisol to assay 12 plasma samples in four laboratories, and compared the results with those obtained with a highly accurate method based on isotope dilution/mass spectrometry. All kits (Farmos, NEN, Sorin, and Clinical Assays) showed 10-50% deviation from the comparison method in the normal range (200-700 nmol/L). The inter- and intralaboratory imprecision (CV) ranged between 8-27% and 5-11%, respectively. Possible explanations for this low accuracy are discussed. Retention of an intact biological matrix in the calibration standards seems to be one prerequisite for accuracy.




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Copyright © 1980 by the American Association for Clinical Chemistry.