Clinical Chemistry
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Clinical Chemistry 26: 1905-1907, 1980;
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Clinical Chemistry, Vol 26, 1905-1907, Copyright © 1980 by American Association for Clinical Chemistry

Evaluation of an enzyme immunoassay for determining diazepam and nordiazepam in serum and urine

JE Wallace, SC Harris and EL Shimek Jr

We evaluated a commercially available enzyme immunoassay method for determining the concentration of total diazepam plus its active metabolite, nordiazepam, in small amounts of serum and urine. The coefficients of variation were 5% within assay and 8% between assay. Concentrations so measured for patients' sera correlated well with those obtained both by gas chromatography with electron-capture detection and by liquid chromatography with ultraviolet detection. For urine samples, the correlation between values obtained by the enzyme immunoassay method and those for total diazepam/nordiazepam/oxazepam obtained by liquid chromatography was adequate for routine clinical toxicological use. The ability of the immunoassay to determine other benzodiazepines was also evaluated.




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Copyright © 1980 by the American Association for Clinical Chemistry.